According to Nakatsue et al., urinary Nphs1 protein, but not Nphs2 protein, was detected in the urine at the early stages of rabbit Heyman nephritis [35], indicating that urinary Nphs1 protein is a useful tool for early diagnosis in the case of Heyman nephritis, although other podocyte markers such as Wt1, Nphs2, and Actn4 are suggested to be helpful for the diagnosis of various kidney diseases [31]–[33]. This evidence concerns the gene NPHS1 and kidney disorder.