To investigate the potential therapeutic value of a secreted NEP targeted to the CNS, we generated lentivirus vectors expressing either the wildtype NEP, a secreted form of the NEP or a secreted form of the NEP fused with the LDL-receptor binding domain of ApoB and injected them intra-peritoneally in an amyloid protein precursor (APP) transgenic (tg) model of AD-like pathology. Here, APP is linked to Alzheimer disease.