CFTR is highly expressed in salivary glands [11], [12], [13], [14], [15], but the reported effects of CF on salivary gland function [6], [7], [8], [16], [17] and the incidence of dental cavities are inconsistent [16], [17], [18], [19], [20], [21]. The gene discussed is CFTR; the disease is cystic fibrosis.