However, the higher Hmgcr expression in BPL is consistent with the elevated hepatic cholesterols (∼1.4-fold, p = 0.025) and plasma cholesterols (∼1.3-fold, p<0.01) in these mice as compared to BPH mice (Mouse Phenome Database, Jackson Laboratory; <www.jax.org/phenome>). This evidence concerns the gene HMGCR and benign prostatic hyperplasia.