Since the BPL- and BPH- Hmgcr did not differ at the SRE-1 or CBF/NF-Y or CRE motifs and the differential expression under the basal conditions was mediated by c-Fos/n-Myc/Max (Fig. 2, 9, 10), the greater sterol-repression (i.e. negative feedback regulation) of the BPL- promoter may be modulated by interaction of SREBP/CBF/NF-Y/CREB with c-Fos/n-Myc/Max. The gene discussed is CREB1; the disease is benign prostatic hyperplasia.