HMGCR and Hypertension: 3-Hydroxy-3-methylglutaryl-coenzyme A [HMG-CoA] reductase gene (Hmgcr/HMGCR) is a candidate gene for hypertension; it translates to the rate-limiting enzyme in the cholesterol biosynthesis pathway and cholesterol is the precursor of glucocorticoid steroid hormones that play a profound role in blood pressure homeostasis and hypertension [3]–[7].