When the induced cell lines were infected with VZV, ORF23 protein colocalized completely with PML IV at 24 hr after infection whereas ORF23 protein was not redistributed to PML-NBs in cells that expressed the truncated PML IV-Δ8AB (Figure 8C), again demonstrating that PML-NBs composed of truncated PML IV were deficient in the sequestration of ORF23 protein, presumed to be on VZV capsids. The gene discussed is PML; the disease is infection.