To our knowledge, these experiments demonstrated for the first time that the same PML isoform has the capacity to sequester both the aberrant poly-Q protein produced in a neurodegenerative disease and a viral capsid protein associated with NC entrapment in PML-NBs and that individual PML cages can simultaneously target and sequester an aberrant polyQ-protein and viral NCs. Here, PROS1 is linked to neurodegenerative disease.