Based on the results of this study, the G0 genes conferring protection from COPD and lung cancer include the rs7671167 SNP (FAM13A gene on the Chr 4q22 locus) and the rs1489759 and rs2202507 SNPs (GYPA and HHIP genes on the Chr 4q31 locus). This evidence concerns the gene FAM13A and chronic obstructive pulmonary disease.