The GG genotype of the HHIP (rs 1489759) SNP was found to be more prevalent in the control group compared to COPD (17% vs 11%, OR = 0.59, P = 0.006) and lung cancer (17% vs 13%, OR = 0.70, P = 0.05) groups (Table 4). This evidence concerns the gene HHIP and lung cancer.