This is in accordance with GDTc expanded from imatinib-treated CML patients, which are predominantly central memory (CD45RA-CD27+) in peripheral blood, yet after expansion with bromohydrin pyrophosphate attain the CD45RA-CD27- effector memory phenotype (Helene Sicard, personal communication, unpublished data). The gene discussed is CD27; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.