We performed cDNA microarray analysis to identify the downstream target genes of SOX2 in gastric cancer cells, and found that many tumor-associated genes exhibited significant changes in expression after SOX2-overexpression (e.g., LTF, PPP2R1B, TGFBR2, SERPINE1, MMP9, HMGA1 and SOX9). This evidence concerns the gene HMGA1 and neoplasm.