In experimental groups in which sustained hyperglycemia correction was attained (diabetic + 1xMSCs, diabetic/insulin + 1xMSCs, diabetic/insulin + 2xMSCs) a significant increase in pancreatic islet number (Figures 3A and B) and an improvement in endogenous insulin production (Figure 3C) were observed. This evidence concerns the gene INS and Hyperglycemia.