Likewise, the function of the carbohydrate response element-binding protein (MLXIPL, a.k.a. ChREBP or WBSCR14) in the regulation of the expression of enzymes involved in glucose and lipid metabolism [39]-[43] suggests that its haploinsufficiency is associated with the higher relative body fat, silent diabetes and/or impaired glucose tolerance found in adult WBS individuals [2]. The gene discussed is MLXIPL; the disease is diabetes mellitus.