AKT1 and malignant colon neoplasm: Conversely, decreased Akt phosphorylation was associated with drug treatment, probably because the cells are undergoing apoptosis; in MiaPaCa-2 cells, as reported in Figure 5B, p-Akt recovered the basic condition after 3 days drug wash out, a similar modulation was observed in colon cancer models, but the recovery, after 3 days wash out, reached at maximum 80% (data not shown).