NES and glioblastoma: We have used three other tumorigenic GBM cell lines, namely LN229, D54 and SNB19, and found that p300 acted as an inducer of GFAP promoter and while inhibiting the Nestin enhancer activity, as measured by luciferase reporter assay; Myc, on the other hand, repressed the GFAP promoter and activated the Nestin enhancer in these cell lines (data not shown).