SNCA and Parkinson disease: In an attempt to mimic the abnormal lysosomal function described in PD (Alvarez-Erviti et al., 2010) we inhibited lysosomal function in normal and WT alpha-synuclein over-expressing SH-SY5Y cells with ammonium chloride for 7 days or with the vacuolar H + ATPase inhibitor bafilomycin A1 for 24 and 72 h (Martinez-Vicente et al., 2008).