The 2008 ovarian cancer cell line expresses both CLDN3 and CLDN4, and we have previously reported on the subline 2008-CLDN3KD-4.5, in which the expression of CLDN3 was knocked down using a lentiviral vector expressing a short hairpin RNA targeted to CLDN3 mRNA [12]. Here, CLDN4 is linked to ovarian carcinoma.