PI3K/AKT inhibitors such as Tipifarnib, cause cell cycle arrest at the G1 or G2/M phase and induce apoptosis of human lung cancer cells [5,6] Our data were consistent with this study and showed that bostrycin treatment induced downregulation of PI3K/AKT signal pathway proteins, caused G0/G1 cell cycle arrest and promoted apoptosis in A549 cells. This evidence concerns the gene AKT1 and lung cancer.