We also demonstrated 1) upregulation of tumor-suppressing transcriptional factors, the noncoding microRNA-638 and microRNA-923, and 2) downregulation of proteins associated with the PI3K/PI3K/AKT signaling pathway in bostrycin-treated cells, suggesting that bostrycin may be a new PI3K/AKT signal pathway-targeting drug for the treatment of pulmonary adenocarcinoma. The gene discussed is AKT1; the disease is neoplasm.