Recombinant microRNA-126 was shown to downregulate the expression of p85β (a regulatory subunit of PI3K related to the stabilization and transmission of the PI3K signal) and p-Akt proteins in rectal cancer cells [27], and microRNA-7 inhibited the Akt pathway and reduced survival rates in spongiocytoma [28]. The gene discussed is PIK3R2; the disease is rectal cancer.