Of these, several proangiogenic chemokines are upregulated in SSc serum including IL-8/CXCL8, growth-regulated oncogene-α (Gro-α/CXCL1), and monocyte chemoattractant protein-1 (MCP-1/CCL2) [9-14]. This evidence concerns the gene CXCL8 and systemic sclerosis.