Given the large difference in outcome found between high and low POLQ expressing tumors, the authors speculate that POLQ may be one of the most important driver genes in other signatures which contain POLQ. Further, they found that cyclin E (CCNE2), amazingly, was the only common gene between all three of the main published prognostic breast cancer signatures and the set of genes positively correlating with POLQ expression. This evidence concerns the gene POLQ and breast cancer.