Because PI3K/Akt and MAPK pathways are often aberrantly activated in tumor cells, and they are reported to be associated with Cdc42 and huntingtin [12,23-25], thus we performed qRT-PCR to determine the mRNA expression of Akt and MAPK14 (encoding p38 MAPK) in Trip10-overexpressed CP70 and IMR-32 cells. The gene discussed is CDC42; the disease is neoplasm.