Fenretinide, a synthetic amide of retinoic acid, has a better toxicological profile acting on both ER+ and ER- breast tumors principally by inducing apoptosis by both retinoic acid receptor (RAR) -dependent and -independent mechanisms; this drug showed a modest chemopreventive effect only in younger premenopausal women [23]. The gene discussed is RARA; the disease is breast neoplasm.