In the hormone-sensitive tumors, tamoxifen acts as a partial antagonist, impairing ER function by competing with estrogen for binding to the receptor [1]; however, more than three years of tamoxifen treatment only results in approximately 50% reduction in the incidence of invasive breast cancer in women at high risk, whereas about a third of ER+ breast tumors are intrinsically resistant to tamoxifen [2,3]. Here, ESR1 is linked to breast neoplasm.