However, an analysis from a separate 6-day phase I study in stable subjects with schizophrenia found similar prolactin pharmacokinetic profiles (Cmax and AUC) when subjects received the highest recommended dose of paliperidone ER (12 mg/day) compared with an average dose of risperidone (4 mg/day) [2]. The gene discussed is PRL; the disease is schizophrenia.