GLA and Fabry disease: The incidence of Fabry’s disease is estimated to be 1:55 000 male births,1 however, due to the constellation of presenting symptoms as well as some mutations allowing limited alphagalactosidase A activity, the actual incidence of Fabry’s, including atypical, sub-clinical or late-variant phenotypes is likely to be much higher, even as high as 1:3 100 male births.8