LEPR and metabolic syndrome: This study group is of particular interest due to the high incidence of both premature CHD and the metabolic syndrome in the South African Indian population.25 The genetic variants selected for study included the adiponectin 45T→G (rs2241766) and 276G→T (rs1501299), the LEPR K109R (rs1173100) and Q223R (rs1173101), the MC4Rassociated C→T (rs17882313) and the FTO A→T (rs9939609) polymorphisms.