MC4R and Obesity: For example, individuals carrying the adiponectin 276G→T polymorphism were found to be associated with type 2 diabetes mellitus in the Japanese population.36 In European subjects, conflicting results have been reported on the relationship between the LEPR Q223R polymorphism and obesity.37,38 Common polymorphisms in the MC4R and the FTO genes have, however, been shown to be predictive of obesity and diabetes.39