Thus, since depression is associated with modifications in proinflammatory cytokines and also with endothelial cell signaling cascades alteration [50] (endothelium is responsible for the synthesis and secretion of BDNF [45], [51]), some detrimental biological modifications caused by TFA with respect to CVD risk could also be responsible for a harmful effect of TFA on depression risk. The gene discussed is BDNF; the disease is major depressive disorder.