CXCL1 and neoplasm: It must be noted however, that expression of many of the chemokines were most often found to be downregulated in the NSCLC tumours as follows CXCL1 (64.9%, p<0.01), CXCL2 (81.1%, p<0.01), CXCL3 (59.5%) (Figure 1B).