CXCR1 and lung cancer: The induction of CXCL8 was significant in HBEC4 and SKMES-1 (p<0.05), as was the increase in CXCR1 and CXCR2 in both the lung cancer cell lines (A549 - p<0.05, SKMES-1 – p<0.01) and CXCR1 in HBEC4 (p<0.05) (Figure 3B).