CXCR1 and lung cancer: Using the histone deacetylase inhibitor (HDACi), Trichostatin A (TSA), an induction of CXCL8 and CXCR1/2 in both the normal (HBEC4) and lung cancer cell lines (A549 and SKMES-1), with a concomitant decrease in CXCL1–3 (SKMES-1, p<0.05) (Figure 3A) was observed.