In addition to calcineurin inhibition, cyclosporine stimulates PDGF [47] and TGFβ [48], [49] signaling that seems to be involved in mediating renin secretory effects of cyclosporine and it is well established that binding of AngII to AGTR1 leads to vasoconstriction and hypertension. This evidence concerns the gene AGTR1 and hypertensive disorder.