While its implication in hepatic disease is over-induction of STAT-6, increased collagen, and fibrosis, reduction of normal levels of IL-4 in the corneal environment may tip the balance toward poor stromal keratocyte cell survival, oxidative stress, altered collagen and ECM stability associated with keratoconus [20], [21], [22], [23]. Here, STAT6 is linked to keratoconus.