AGT and Alzheimer disease: Moreover, some studies also showed that Ang II could inhibit potassium-mediated release of acetylcholine [26], [27], induce oxidative stress[28], activation of mitogen-activated protein kinases (MAPKs) [29], and inflammation [30], and was involved in blood–brain barrier maintenance [31] and cell survival [32], all of which are relevant to AD [32]–[35].