Here we report that EZH2 is up-regulated in angiogenic endothelial cells and that miR-101 is down-regulated in primary endothelial cells exposed to VEGF or glioblastoma cells, as well as in blood vessel endothelial cells that were isolated from vascularized glioblastomas from patient samples. The gene discussed is EZH2; the disease is glioblastoma.