EZH2 and glioblastoma: To establish whether tumor-derived soluble factors are sufficient to induce differential expression of miR-101 and EZH2, HBMVEC cells were cultured in endothelial basal medium (EBM), EBM supplemented with an angiogenic cocktail (EGM), or EBM conditioned culture medium derived from U87 glioblastoma cells (U87cm).