Upon examination of the EZH2 immunohistochemistry of vascularized glioblastoma and non-neoplastic brain tissue slices, we noticed positive nuclear staining for EZH2 in the endothelial cells of newly formed blood vessels in the glioblastoma samples, but not in the non-neoplastic brain tissues (Fig. 2C). The gene discussed is EZH2; the disease is glioblastoma.