The ratio of Apo A-IV/Alb in CSF of HD patients (0.12 [0.08 to 0.15]) was significantly higher than that of controls (0.06 [0.03 to 0.09]) (p = 0.005), while ratio of Apo A-IV/Alb in serum of HD patients (0.23 [0.19 to 0.29]) was not different from those of controls (0.31 [0.23 to 0.39]). The gene discussed is ALB; the disease is Huntington disease.