Figure 2a shows an exposure that illustrates the differential banding patterns between genotypes. Densitometry data, which was obtained from a lower exposure than that shown, were averaged over 3 blots with ‘n’s of 9, 13, and 11 (cognitively normal, AD 3/3, and AD 4/4). The total concentration of ApoE was found to be significantly elevated in AD patients with APOEε3/3 genotype (p<0.001) and APOEε4/4 genotype (p<0.0001 figure 2b). The gene discussed is APOE; the disease is Alzheimer disease.