The same pattern of differences in the other lymphatic markers, eg., Prox-1 and VEGFR-3 in the normal lymphatics (Figure 9G, Figure 9H) versus the lymphatics containing tumor emboli (Figure 9I) was observed with both Prox-1 and VEGFR-3 similarly more negative and less circumferential in the lymphatics containing tumor emboli (p=0.01) (p=0.01). This evidence concerns the gene PROX1 and neoplasm.