There were differences in the the presence versus the absence and in the circumferential distribution of CD31 and D2-40, Prox-1 and VEGFR-3 immunoreactivities within the normal vessels in the breast cancer sections compared to those vessels containing tumor emboli (p=.01), (p=.01) (Figure 9D; Figure 9E; Figure 9F) (Table 3). This evidence concerns the gene PROX1 and neoplasm.