The results of two studies of CRP and obesity using a similar Mendelian randomization approach also contradict each other, with one reporting CRP is causally and positively related to BMI in women (Bochud et al., 2009), while another arguing that there is no evidence that higher CRP level causes greater adiposity (Welsh et al., 2010). The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.