CRP and major depressive disorder: Despite a large number of studies linking depression and anxiety to elevated CRP level (Bankier et al., 2009; Howren et al., 2009; Pitsavos et al., 2006), so far there has been only two studies investigating CRP genetic variants in depression (Almeida et al., 2009; Halder et al., 2010), and none investigating these CRP variants and the metabolic syndrome in those with affective symptoms.