CRP and major depressive disorder: Higher CRP plasma levels have been shown to be associated with both the metabolic syndrome (Devaraj et al., 2009) and depression (Raison et al., 2006; Gimeno et al., 2009; Howren et al., 2009) and anxiety (Bankier et al., 2009; Pitsavos et al., 2006), although some studies failed to confirm these associations (Douglas et al., 2004; O’Donovan et al., 2010; Whooley et al., 2007).