Our previous study showed that the expression of Akt total protein in Lewis y antigen-overexpressed ovarian cancer cells did not change, but it phosphorylation was significantly enhanced; ZD1839 and Lewis y antibody decreased the level of phosphorylated Akt in Lewis y antigen-overexpressed cells, but showed no effect in the ovarian cancer cells with low Lewis y antigen expression. This evidence concerns the gene AKT1 and ovarian carcinoma.