In the pathological investigation of three patients complicated with paraneoplastic cerebellar ataxia and LEMS, Fukuda et al. reported that a loss of Purkinje cells in the cerebellum was evident but HE staining and immunostaining using CD3, CD4, CD19, and CD20 did not demonstrate infiltration of lymphocytes in the cerebellar cortex [13]. This evidence concerns the gene CD4 and Lambert-Eaton myasthenic syndrome.