The induction of IFN-γ in the tumor microenvironment and spleen of Meth-A-bearing mice by triple i.p. injection of EJHE-WR and EJHE, respectively, is probably connected with their constituents enhancing effect allowing the intratumoral penetration of antitumor effectors and polarizing towards Th1 response from macrophages and DCs produced IL-12 which in turn can support IFN-γ production noticed within the microenvironment [43]. The gene discussed is IFNG; the disease is neoplasm.