TNF and neoplasm: However, this favorable induction of IFN-γ by EJHE-WR within the tumor microenvironment was accompanied by TGF-β1 induction, probably along with an inflammatory cytokine e.g. TNF-α [10,42] that is common in such microenvironment, may further supports Th17 differentiation and thus induce IL-17 production as well [44].