The present study extended the latter observation of EJHE modulatory effects on IFN-γ, TGF-β1 as a representative of T regulatory (Treg) cells, and IL-17 as an indicator of T helper (Th) 17 cells in normal tissues as well as in Meth-A-fibrosarcoma tumor-bearing mice [11]. This evidence concerns the gene TGFB1 and fibrosarcoma.