For instance, 24 hours post administration of EHJE or EJHE-WR, the TGF-β to IFN-γ ratio in the spleen of healthy mice became ~30 in comparison to 300 in PBS-injected mice whereas this ratio either did not change or increased upon administration of EHJE and EHJE-WR in tumor-bearing mice. This evidence concerns the gene TGFB1 and neoplasm.