Some of the genes upregulated in these EGIR-harvested stratum corneum specimens overlying melanoma are shown in Figure 2 including KIT, tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), dopachrome tautomerase (DCT), SOX10 and PAX3 – all of which are involved in melanocyte development and pigmentation. The gene discussed is PAX3; the disease is melanoma.