Becausev (1) depolarization-induced Ca2+ release is affected by the loss CAV3 (Fig. 3) [Couchoux et al., 2007], (2) studies by Vassilopoulos et al. [2010] demonstrated a direct interaction between CAV3 and the RyR1, and (3) ECCE depends on the presence of the DHPR and of the RyR, we studied ECCE in the myotubes from the two RMD patients. Here, RYR1 is linked to inherited rippling muscle disease.