CAV3 and rippling muscle disease: Although their exact physiological role is not clear, the above data indicate that caveolin-3 plays an important role in muscle function and mutations in CAV3 have indeed been linked to several hereditary myopathies, among which are Limb Girdle Muscular Dystrophy (LGMD; MIM♯ 607801), Rippling Muscle Disease (RMD; MIM♯ 606072), Distal myopathy (DM; MIM♯ 601253), and HyperCKemia [Betz et al., 2001; Gazzerro et al., 2010; Woodman et al., 2004].