CAV3 and rippling muscle disease: Rippling muscle disease (RMD; MIM♯ 606072) is a rare autosomal dominant disorder caused by mutations in CAV3 (MIM♯ 601253) the gene encoding caveolin-3 (CAV3), a caveolin isoform exclusively expressed in skeletal, cardiac, and smooth muscles [Betz et al., 2001; Woodman et al., 2004].