Finally, these studies can provide insight and raise new questions regarding the role of PLZF in both leukemia development and stem cell maintenance [2-5, 7]; do the fusion proteins of t(11;17) APL drive leukemogenesis in part, through opposing PLZF-regulated cytoskeletal architecture and does this mechanism of PLZF action have a role in stem cell biology? Here, ZBTB16 is linked to leukemia.