Nevertheless, not only did the early expansion of intestinal CD4+CCR5+ T cells, detectable from day 3, appear to "fuel" the increases in plasma SIV RNA loads at days 3 and 7, but also the loss of LPL and IEL CD4+CCR5+ TEM cells from day 7 also augured the end of the primary viraemia from day 10 when there were dramatic reductions in remaining LPL and IEL CD4+CCR5+ TTrM-2 cells to pre-infection levels. The gene discussed is CD4; the disease is infection.