Additional proteins found to be upregulated in EBV associated disease, such as CXCL13 in NPC and CD30 in Hodgkin's disease (HD) (and in some NPC), were also detected at high levels in the transgenic tissue, but not in the SCC12F cell line system, suggesting that these may result from in vivo interactions. This evidence concerns the gene TNFRSF8 and Huntington disease.