PDLIM7 and Hyperkeratosis: The ears of the L2LMP1CAO mice (the tissue where LMP1 is expressed at the highest level) and to a lesser extent other regions of body skin develop a preneoplastic pathology of hyperplasia with increased vascularisation, progressing to acanthosis, hyperkeratosis, parakeratosis and erosive or ulcerative dermatitis, which can lead to the development of keratoacanthoma, papilloma and ultimately carcinoma.