AGBL2 and rheumatoid arthritis: Patients with recent onset RA and positive for IgA anti-CCP2 antibodies were reported to suffer a more severe disease course over the first three years compared with patients negative for IgA anti-CCP2 antibodies [10] and the number of different isotypes has recently been related to the long-term radiographic progression in anti-CCP2 antibody positive RA patients [11].