This finding was confirmed in animal model with xenografts of HNSCC that cisplatin enhanced AAV-mediated TRAIL expression and augmented the antitumor activity of AAV/TRAIL, suggesting that combination of AAV/TRAIL and cisplatin is significantly effective in the treatment of HNSCC and may lead to reduction of the cisplatin toxicity. This evidence concerns the gene TNFSF10 and head and neck squamous cell carcinoma.