F5 and escherichia coli infection: For the treatment of bovine colibacillosis caused by enterotoxigenic E. coli (ETEC), Bhaskaran et al. [29] developed a recombinant anti-F5 scFv fragment that inhibits the hemmaglutination of horse red blood cells by F5 protein, which would be expected to inhibit the binding of F5-expressing ETEC to intestinal cells.