A recent study based on lentiviral vectors encoding microRNA against OPN reveals that silencing OPN can dramatically inhibits in both in vitro invasion and in vivo lung metastasis of HCCLM3 cells, even could suppress in vitro proliferation and in vivo tumor growth of HCCLM3 by interrupting MAPK pathway and NF-κB pathway [125], which suggests that OPN could be a hopeful target for the control of metastasis as well as HCC tumor growth and viral vector-mediated microRNA against OPN can be treated as a new therapeutics. Here, SPP1 is linked to neoplasm.