GPT and cancer: Reactivation of HBV replication with an increase in serum HBV DNA and alanine aminotransferase (ALT) activity has been reported in 20–50% of hepatitis B carriers undergoing cytotoxic chemotherapy for cancer treatment (Yeo et al, 2000, 2003, 2004b; Idilman et al, 2004; Lok and McMahon, 2007).