In contrast, the prognostic relevance of KRAS genotype in CRC has been controversial despite a number of multi-institutional investigations dating from the 1990s (Andreyev et al, 1998; French et al, 2008; Kakar et al, 2008; Ogino et al, 2009; Roth et al, 2010). This evidence concerns the gene KRAS and colorectal carcinoma.