Despite a slightly higher (nonsignificant) PSA response rate (68%) in the DAiS arm (with immediate use of Diethylstilbestrol), deferring its use until failure of Dexamethasone and aspirin (response rate 64%) might be the preferred strategy as PFS, overall survival, and quality of life did not reduce significantly, and there was a significantly reduced number of VTEs and painful gynaecomastia. This evidence concerns the gene KLK3 and Gynecomastia.