Biochemical changes have been modest, all were grade 1 in patients with normal baseline chemistries except one patient with myositis who experienced a grade 3 CPK elevation, 3 patients at 60 mg who had grade 2 raised AST and hyperbilirubinemia and two patients at that same dose level who had grade 3 ALT rise. Here, PIK3C2A is linked to Hyperbilirubinemia.