In addition, ALKBH3 silencing through siRNA transfection effectively induced cellular senescence and growth suppression of lung adenocarcinoma cells both in vivo and in vitro. AlkB homologue-3 may thus join EGFR as both a new molecular target in cancer therapeutics and as another useful clinicopathological marker in the management of human non-small-cell lung cancer. Here, EGFR is linked to lung adenocarcinoma.