Immunohistochemistry clearly showed that ALKBH3 was highly expressed in human NSCLC, both in adenocarcinomas and in squamous cell carcinomas, but ALKBH3 expression profiles correlated, in a statistically significant manner, to recurrence-free survival only in cases of adenocarcinoma, implicating ALKBH3 expression as a useful diagnostic and prognostic factor for adenocarcinoma outcome. The gene discussed is ALKBH3; the disease is squamous cell carcinoma.