AKT1 and neoplasm: This study provided several results including the following: (1) VEGF-A and COX-2 mRNA were upregulated in mouse TECs isolated from tumour xenografts; (2) HuR was highly expressed in the cytoplasm of cultured mouse TECs and human TECs in vivo; (3) HuR bound to VEGF-A and COX-2 mRNAs and stabilised them in the TEC cytoplasm; (4) HuR knockdown led to the inhibition of cell survival, random motility, and tube formation in TECs; and (5) HuR knockdown suppressed Akt phosphorylation and TECs tube formation.